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New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.

Abstract:

A sequence element located immediately upstream of the TATA element, and having the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3', affects the ability of transcription factor IIB to enter transcription complexes and support transcription initiation. The sequence element is recognized directly by the transcription factor IIB. Recognition involves alpha-helices 4' and 5' of IIB, which comprise a helix-turn-helix DNA-binding motif. These observations establish that transcription initiation involv...

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Publisher copy:
10.1101/gad.12.1.34

Authors


Lagrange, T More by this author
Kapanidis, AN More by this author
Reinberg, D More by this author
Ebright, RH More by this author
Journal:
Genes and development
Volume:
12
Issue:
1
Pages:
34-44
Publication date:
1998-01-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:ccbe664a-eaf8-4adc-8cb4-b64a700053d9
Source identifiers:
8231
Local pid:
pubs:8231

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