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Journal article

No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.

Abstract:

Multiple sclerosis (MS) is a complex neurological disease with huge variability in disease outcome. The majority of MS genetic susceptibility is determined by major histocompatibility complex (MHC) alleles, in particular haplotypes carrying HLA-DRB1*1501. HLA-DRB1*1501 also affects the clinical outcome of the disease and animal research has suggested that HLA-DRB5 interacts with HLA-DRB1*1501 to influence disease severity. We used an extremes-of-outcome design with 48 benign and 20 malignant ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Journal of neuroimmunology More from this journal
Volume:
223
Issue:
1-2
Pages:
120-123
Publication date:
2010-06-01
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
Language:
English
Keywords:
Pubs id:
pubs:53308
UUID:
uuid:ccbc64e1-6a00-4b6f-bd10-ecef7181eeb0
Local pid:
pubs:53308
Source identifiers:
53308
Deposit date:
2012-12-19

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