The impact of critical point drying with liquid carbon dioxide on collagen-hydroxyapatite composite scaffolds.

Journal article

Collagen-hydroxyapatite composites for bone tissue engineering are usually made by freezing an aqueous dispersion of these components and then freeze-drying. This method creates a foamed matrix which may not be optimum for growing cell colonies larger than a few hundred micrometres due to the limited diffusion of nutrients and oxygen, and the limited removal of waste metabolites. Incorporating a network of microchannels in the interior of the scaffold which may permit the flow of nutrient-ric...

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Authors: Sachlos, E; Wahl, D; Triffitt, J; Czernuszka, J

• Publication status: Published
• Journal: Acta biomaterialia
• Volume: 4
• Issue: 5
• Pages: 1322-1331
• Publication date: 2008-09-01
• DOI: 10.1016/j.actbio.2008.03.016
• EISSN: 1878-7568
• ISSN: 1742-7061
• Language: English
• Keywords: Equipment Failure Analysis; Durapatite; Desiccation; Surface Properties; Cell Line; Bone Substitutes; Osteoblasts; Solutions; Biocompatible Materials; Humans; Carbon Dioxide; Collagen