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The impact of critical point drying with liquid carbon dioxide on collagen-hydroxyapatite composite scaffolds.

Abstract:

Collagen-hydroxyapatite composites for bone tissue engineering are usually made by freezing an aqueous dispersion of these components and then freeze-drying. This method creates a foamed matrix which may not be optimum for growing cell colonies larger than a few hundred micrometres due to the limited diffusion of nutrients and oxygen, and the limited removal of waste metabolites. Incorporating a network of microchannels in the interior of the scaffold which may permit the flow of nutrient-ric...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Role:
Author
Journal:
Acta biomaterialia More from this journal
Volume:
4
Issue:
5
Pages:
1322-1331
Publication date:
2008-09-01
DOI:
EISSN:
1878-7568
ISSN:
1742-7061
Language:
English
Keywords:
Pubs id:
pubs:24797
UUID:
uuid:ccb19fd1-4ee4-4809-83c4-c96a02822d5b
Local pid:
pubs:24797
Source identifiers:
24797
Deposit date:
2012-12-19

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