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Theoretical conditions for the coexistence of viral strains with differences in phenotypic traits: a bifurcation analysis

Abstract:

We investigate the dynamics of a wild-type viral strain which generates mutant strains differing in phenotypic properties for infectivity, virulence and mutation rates. We study, by means of a mathematical model and bifurcation analysis, conditions under which the wild-type and mutant viruses, which compete for the same host cells, can coexist. The coexistence conditions are formulated in terms of the basic reproductive numbers of the strains, a maximum value of the mutation rate and the viru...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsos.181179

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Department:
Unknown
Role:
Author
ORCID:
0000-0002-5928-6256
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Funding agency for:
Hennessy, M
Grant:
707658
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Funding agency for:
Sardanyes, J
Grant:
RYC-2017-22243
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Funding agency for:
Elena, S
Grant:
BFU2015-65037-P
‘la Caixa’ Foundation More from this funder
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Publisher:
Royal Society Publisher's website
Journal:
Royal Society Open Science Journal website
Volume:
6
Issue:
1
Article number:
181179
Publication date:
2019-01-09
Acceptance date:
2018-11-26
DOI:
ISSN:
2054-5703
Source identifiers:
953030
Pubs id:
pubs:953030
UUID:
uuid:ccaa3bbb-d5a1-4d62-adb7-a9e055c7ebc5
Local pid:
pubs:953030
Deposit date:
2018-12-17

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