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Adaptation of Plasmodium falciparum to its transmission environment

Abstract:

Success in eliminating malaria will depend on whether parasite evolution outpaces control efforts. Here, we show that Plasmodium falciparum parasites (the deadliest of the species causing human malaria) found in low-transmission-intensity areas have evolved to invest more in transmission to new hosts (reproduction) and less in within-host replication (growth) than parasites found in high-transmission areas. At the cellular level, this adaptation manifests as increased production of reproducti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41559-017-0419-9

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
ORCID:
0000-0002-7255-821X
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Role:
Author
ORCID:
0000-0002-9605-0154
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Ecology & Evolution Journal website
Volume:
2
Pages:
377–387
Publication date:
2017-12-18
Acceptance date:
2017-11-20
DOI:
EISSN:
2397-334X
Pmid:
29255304
Source identifiers:
812732
Language:
English
Keywords:
Pubs id:
pubs:812732
UUID:
uuid:ccaa2ae1-40a4-4fc5-9fb0-b0cc44af4ffc
Local pid:
pubs:812732
Deposit date:
2018-01-04

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