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Solution conformation of a parallel DNA triple helix with 5' and 3' triplex-duplex junctions.

Abstract:

BACKGROUND: Polypurine x polypyrimidine sequences of DNA can form parallel triple helices via Hoogsteen hydrogen bonds with a third DNA strand that is complementary to the purine strand. The triplex prevents transcription and could therefore potentially be used to regulate specific genes. The determination of the structures of triplex-duplex junctions can help us to understand the structural basis of specificity, and aid in the design of optimal antigene oligonucleotides. RESULTS: The solutio...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Structure (London, England : 1993) More from this journal
Volume:
7
Issue:
1
Pages:
1-11
Publication date:
1999-01-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
Keywords:
Pubs id:
pubs:400258
UUID:
uuid:cca87b98-4f2b-4556-b71d-096dbea98986
Local pid:
pubs:400258
Source identifiers:
400258
Deposit date:
2013-11-16

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