An estimate of the turnover rate of bone-derived plasma alkaline phosphatase in Paget's disease.

Journal article

A through-knee amputation for suspected osteogenic sarcoma was performed on a patient with Paget's disease of the tibia. Plasma alkaline phosphatase (AP) activity fell to normal values, apparently as a single exponential function of time, with a half-life of 1.7 days. The daily turnover of bone-derived plasma AP was estimated to be approximately 200 I.U. from the Pagetic tibia and 20 I.U. from the rest of the skeleton.

Authors: Walton, R; Preston, C; Russell, R; Kanis, J

• Publication status: Published
• Journal: Clinica chimica acta; international journal of clinical chemistry
• Volume: 63
• Issue: 2
• Pages: 227-229
• Publication date: 1975-09-01
• DOI: 10.1016/0009-8981(75)90167-9
• EISSN: 1873-3492
• ISSN: 0009-8981
• Language: English
• Keywords: Tibia; Humans; Half-Life; Bone and Bones; Osteitis Deformans; Middle Aged; Male; Alkaline Phosphatase