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Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis

Abstract:

Background: Randomised controlled trials (RCTs) of anti-EGFR monoclonal antibodies (MAb) in patients with advanced colorectal cancer (aCRC) have reported conflicting results. Methods: A systematic review of RCTs comparing standard treatments ± anti-EGFR MAbs was conducted. Hazard ratios (HR) for progression-free (PFS) and overall survival (OS) were derived for patients with wild-type (WT) and mutant KRAS. Prespecified analyses were conducted for line of treatment, MAb used, chemotherapy regim...

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Publisher copy:
10.1016/j.ctrv.2011.11.002

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Journal:
Cancer Treatment Reviews
Volume:
38
Issue:
6
Pages:
618-625
Publication date:
2012-10-01
DOI:
EISSN:
1532-1967
ISSN:
0305-7372
Source identifiers:
340269
Language:
English
Keywords:
Pubs id:
pubs:340269
UUID:
uuid:cca24c83-60ca-43b5-9e38-e430d415be6c
Local pid:
pubs:340269
Deposit date:
2013-11-16

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