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The histone deacetylase inhibitor romidepsin spares normal tissues while acting as an effective radiosensitiser in bladder tumours in vivo

Abstract:

Purpose:
Muscle-invasive bladder cancer has a 40% to 60% 5-year survival rate with radical treatment by surgical removal of the bladder or radiation therapy–based bladder preservation techniques, including concurrent chemoradiation. Elderly patients cannot tolerate current chemoradiation therapy regimens and often receive only radiation therapy, which is less effective. We urgently need effective chemotherapy agents for use with radiation therapy combinations that ar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ijrobp.2020.01.015

Authors


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Name:
Cancer Research UK
Grant:
C5255/A23755
Publisher:
Elsevier
Journal:
International Journal of Radiation: Oncology - Biology - Physics More from this journal
Volume:
107
Issue:
1
Pages:
212-221
Publication date:
2020-01-25
Acceptance date:
2020-01-14
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Language:
English
Keywords:
Pubs id:
pubs:1082552
UUID:
uuid:cc942a87-4499-436f-a7b7-2068d7b9bdb8
Local pid:
pubs:1082552
Source identifiers:
1082552
Deposit date:
2020-01-15

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