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Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.

Abstract:

Mammalian mitochondria can be transferred between cells both in culture and in vivo. There is evidence that isolated mitochondria enter cells by endocytosis, but the mechanism has not been fully characterised. We investigated the entry mechanism of isolated mitochondria into human osteosarcoma (HOS) cells. Initially we confirmed that respiratory-competent cells can be produced following incubation of HOS cells lacking mitochondrial DNA (mtDNA) with functional exogenous mitochondria and select...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Department:
H5 HUMAN GENETICS WT CENTRE
Role:
Author
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Name:
Medical Research Council
Grant:
MC_U105697135
Publisher:
Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
7
Issue:
1
Pages:
12886
Publication date:
2017-10-01
Acceptance date:
2017-09-20
DOI:
EISSN:
2045-2322
Pmid:
29018288
Language:
English
Keywords:
Pubs id:
pubs:735446
UUID:
uuid:cc8cef01-b83f-4802-89a3-50d9e5ccee28
Local pid:
pubs:735446
Source identifiers:
735446
Deposit date:
2017-10-17

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