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Thesis

Engineering carboxymethylproline synthases towards the biosynthetic productions of carbapenem antibiotics

Abstract:

Mechanistic and biocatalytic studies of two carboxymethylproline synthases (CMPSs), CarB and ThnE, members of the crotonase superfamily of enzymes, both in isolation and in conjunction with the activity of the crotonyl-CoA carboxylase/reductase (Ccr) the malonyl-CoA synthetase (MatB) and the methylmalonyl-CoA epimerase (MCE) are presented.

Protein engineering studies on carboxymethylproline synthases aimed at enabling stereoselective C–C bond formation leading to N-heterocy...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author

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Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:cc8c9b07-0f3a-4dea-bd97-e2ca2e2d3a41
Local pid:
ora:7558
Deposit date:
2013-11-05

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