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Engineering carboxymethylproline synthases towards the biosynthetic productions of carbapenem antibiotics

Abstract:

Mechanistic and biocatalytic studies of two carboxymethylproline synthases (CMPSs), CarB and ThnE, members of the crotonase superfamily of enzymes, both in isolation and in conjunction with the activity of the crotonyl-CoA carboxylase/reductase (Ccr) the malonyl-CoA synthetase (MatB) and the methylmalonyl-CoA epimerase (MCE) are presented.

Protein engineering studies on carboxymethylproline synthases aimed at enabling stereoselective C–C bond formation leading to N-heterocy...

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemical Biology
Role:
Author

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Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:cc8c9b07-0f3a-4dea-bd97-e2ca2e2d3a41
Local pid:
ora:7558

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