Radio-opaque agents in bone cement increase bone resorption.

Journal article

A heavy infiltrate of foreign-body macrophages is commonly seen in the fibrous membrane which surrounds an aseptically loose cemented implant. This is in response to particles of polymethylmethacrylate (PMMA) bone cement and other biomaterials. We have previously shown that monocytes and macrophages responding to particles of bone cement are capable of differentiating into osteoclastic cells which resorb bone. To determine whether the radio-opaque additives barium sulphate (BaSO4) and zirconi...

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Authors: Sabokbar, A; Fujikawa, Y; Murray, D; Athanasou, N

• Publication status: Published
• Journal: Journal of bone and joint surgery. British volume
• Volume: 79
• Issue: 1
• Pages: 129-134
• Publication date: 1997-01-01
• DOI: 10.1302/0301-620x.79b1.6966
• ISSN: 0301-620X
• Language: English
• Keywords: Monocytes; Osteoclasts; Barium Sulfate; Female; Osteoblasts; Cells, Cultured; Cell Differentiation; Isoenzymes; Contrast Media; Bone Resorption; Methylmethacrylates; Acid Phosphatase; Mice; Bone Cements; Prosthesis Failure; Zirconium; Animals