MHC class II proteins and disease: a structural perspective.

Journal article

MHC class II molecules on the surface of antigen-presenting cells display a range of peptides for recognition by the T-cell receptors of CD4+ T helper cells. Therefore, MHC class II molecules are central to effective adaptive immune responses, but conversely, genetic and epidemiological data have implicated these molecules in the pathogenesis of autoimmune diseases. Indeed, the strength of the associations between particular MHC class II alleles and disease render them the main genetic risk f...

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Authors: Jones, E; Fugger, L; Strominger, J; Siebold, C

• Publication status: Published
• Journal: Nature reviews. Immunology
• Volume: 6
• Issue: 4
• Pages: 271-282
• Publication date: 2006-04-01
• DOI: 10.1038/nri1805
• EISSN: 1474-1741
• ISSN: 1474-1733
• Language: English
• Keywords: Humans; Models, Molecular; HLA-D Antigens; Binding Sites; Autoimmune Diseases; Protein Conformation; Protein Binding; Epitopes, T-Lymphocyte