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MHC class II proteins and disease: a structural perspective.

Abstract:

MHC class II molecules on the surface of antigen-presenting cells display a range of peptides for recognition by the T-cell receptors of CD4+ T helper cells. Therefore, MHC class II molecules are central to effective adaptive immune responses, but conversely, genetic and epidemiological data have implicated these molecules in the pathogenesis of autoimmune diseases. Indeed, the strength of the associations between particular MHC class II alleles and disease render them the main genetic risk f...

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Publication status:
Published

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Publisher copy:
10.1038/nri1805

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Nature reviews. Immunology More from this journal
Volume:
6
Issue:
4
Pages:
271-282
Publication date:
2006-04-01
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
Language:
English
Keywords:
Pubs id:
pubs:12950
UUID:
uuid:cc86747a-036c-40d3-8f9d-b501b300c0dc
Local pid:
pubs:12950
Source identifiers:
12950
Deposit date:
2012-12-19

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