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CD8+ T effector memory cells protect against liver-stage malaria

Abstract:

Identification of correlates of protection for infectious diseases including malaria is a major challenge and has become one of the main obstacles in developing effective vaccines.We investigated protection against liver-stage malaria conferred by vaccination with adenoviral (Ad) and modified vaccinia Ankara (MVA) vectors expressing pre-erythrocytic malaria Ags. By classifying CD8+ T cells into effector, effector memory (TEM), and central memory subsets using CD62L and CD127 markers, we found...

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Publisher copy:
10.4049/jimmunol.1100302

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Journal:
Journal of Immunology
Volume:
187
Issue:
3
Pages:
1347-1357
Publication date:
2011-08-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:cc84a91e-c13c-43b7-b169-b8deec8200dd
Source identifiers:
179395
Local pid:
pubs:179395
Language:
English

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