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p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes.

Abstract:

Despite extensive studies on the role of tumor suppressor p53 protein and its homologues, p73 and p63, following their overexpression or cellular stress, very little is known about the regulation of the three proteins in cells during physiologic cell cycle progression. We report a role for p73 and p63 in supporting cellular proliferation through the transcriptional activation of the genes involved in G(1)-S and G(2)-M progression. We found that in MCF-7 cells, p73 and p63, but not p53, are mo...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Cancer research
Volume:
69
Issue:
22
Pages:
8563-8571
Publication date:
2009-11-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:cc831684-5e9d-46cc-8e72-b252f0d5c507
Source identifiers:
370034
Local pid:
pubs:370034

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