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HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades.

Abstract:

OBJECTIVES: To investigate HLA class I allele frequencies in a Kenyan commercial sex worker (CSW) cohort, and to examine HIV-1 specific cytotoxic T lymphocyte (CTL) responses directed against epitopes derived from locally prevalent clade A virus. METHODS: PCR-single strand polymorphism HLA class I typing. Sequencing of novel alleles and examination of their distribution in the CSW cohort, and a low risk HIV uninfected cohort. The peptide-binding motif of a novel class I allele was predicted,...

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Publication status:
Published

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Journal:
AIDS (London, England) More from this journal
Volume:
16
Issue:
14
Pages:
1899-1904
Publication date:
2002-09-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370

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