HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades.

Journal article

OBJECTIVES: To investigate HLA class I allele frequencies in a Kenyan commercial sex worker (CSW) cohort, and to examine HIV-1 specific cytotoxic T lymphocyte (CTL) responses directed against epitopes derived from locally prevalent clade A virus. METHODS: PCR-single strand polymorphism HLA class I typing. Sequencing of novel alleles and examination of their distribution in the CSW cohort, and a low risk HIV uninfected cohort. The peptide-binding motif of a novel class I allele was predicted,...

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Authors: Bird, T; Kaul, R; Rostron, T; Kimani, J; Embree, J

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 16
• Issue: 14
• Pages: 1899-1904
• Publication date: 2002-09-01
• DOI: 10.1097/00002030-200209270-00006
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: Gene Frequency; T-Lymphocytes, Cytotoxic; Prostitution; Cohort Studies; Polymerase Chain Reaction; HLA Antigens; Sequence Analysis; Female; Polymorphism, Single-Stranded Conformational; Epitopes, T-Lymphocyte; HIV-1; Genotype; Oxford-Nairobi HLA Collaborative Group; Humans; Histocompatibility Antigens Class I; Kenya