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Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.

Abstract:

The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human first-trimester fetal blood mesenchymal stem cells (MSCs) into homozygous oim mice in utero. This resulted in a two-thirds reduction in long bone fractures (P < .01), with fewer fractures per mouse (median 1, range 0-2 in mice that received transplants vs median 3, range 1-5 in mice that did not receive transplants by 12 weeks, P < .01)....

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Journal:
Blood
Volume:
111
Issue:
3
Pages:
1717-1725
Publication date:
2008-02-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
223517
Language:
English
Keywords:
Pubs id:
pubs:223517
UUID:
uuid:cc7a843e-abd0-4af0-81ba-3879af04c606
Local pid:
pubs:223517
Deposit date:
2013-11-16

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