- Abstract:
-
The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human first-trimester fetal blood mesenchymal stem cells (MSCs) into homozygous oim mice in utero. This resulted in a two-thirds reduction in long bone fractures (P < .01), with fewer fractures per mouse (median 1, range 0-2 in mice that received transplants vs median 3, range 1-5 in mice that did not receive transplants by 12 weeks, P < .01)....
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2007-08-105809
-
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- Journal:
- Blood
- Volume:
- 111
- Issue:
- 3
- Pages:
- 1717-1725
- Publication date:
- 2008-02-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
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0006-4971
- URN:
-
uuid:cc7a843e-abd0-4af0-81ba-3879af04c606
- Source identifiers:
-
223517
- Local pid:
- pubs:223517
- Copyright date:
- 2008
Journal article
Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.
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