Journal article icon

Journal article

Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.

Abstract:

The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human first-trimester fetal blood mesenchymal stem cells (MSCs) into homozygous oim mice in utero. This resulted in a two-thirds reduction in long bone fractures (P < .01), with fewer fractures per mouse (median 1, range 0-2 in mice that received transplants vs median 3, range 1-5 in mice that did not receive transplants by 12 weeks, P < .01)....

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Guillot, PV More by this author
Bassett, JH More by this author
Shefelbine, SJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Expand authors...
Journal:
Blood
Volume:
111
Issue:
3
Pages:
1717-1725
Publication date:
2008-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:cc7a843e-abd0-4af0-81ba-3879af04c606
Source identifiers:
223517
Local pid:
pubs:223517

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP