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Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

Abstract:

Epithelial cells organize into cyst-like structures that contain a spherical monolayer of cells that enclose a central lumen. Using a three-dimensional basement membrane culture model in which mammary epithelial cells form hollow, acinus-like structures, we previously demonstrated that lumen formation is achieved, in part, through apoptosis of centrally localized cells. We demonstrate that the proapoptotic protein Bim may selectively trigger apoptosis of the centrally localized acinar cells, ...

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Publication status:
Published

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Authors


Reginato, MJ More by this author
Becker, EB More by this author
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Journal:
Molecular and cellular biology
Volume:
25
Issue:
11
Pages:
4591-4601
Publication date:
2005-06-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:cc788d04-3b74-46be-9e57-7413f0bc6ba7
Source identifiers:
248014
Local pid:
pubs:248014

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