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Development of isotope-enriched phosphatidylinositol-4-and 5-phosphate cellular mass spectrometry probes

Abstract:

Synthetic phosphatidylinositol phosphate (PtdInsPn) derivatives play a pivotal role in broadening our understanding of PtdInsPn metabolism. However, the development of such tools is reliant on efficient enantioselective and regioselective synthetic strategies. Here we report the development of a divergent synthetic route applicable to the synthesis of deuterated PtdIns4P and PtdIns5P derivatives. The synthetic strategy developed involves a key enzymatic desymmetrisation step using Lipozyme TL...

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Publication status:
Published

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Publisher:
Royal Society of Chemistry
Journal:
Chemical Science More from this journal
Volume:
12
Issue:
7
Pages:
2549-2557
Publication date:
2020-12-28
Acceptance date:
2020-12-28
DOI:
EISSN:
2041-6539
ISSN:
2041-6520
Language:
English
Keywords:
Pubs id:
1167476
Local pid:
pubs:1167476
Deposit date:
2021-05-05

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