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Interaction of human monocytes, macrophages, and polymorphonuclear leukocytes with zymosan in vitro. Role of type 3 complement receptors and macrophage-derived complement.

Abstract:

Macrophages take up zymosan in the absence of exogenous complement via receptors for iC3b (type 3 complement receptors) acting with or without lectin-like receptors for mannosyl-fucosyl-terminated glycoconjugates. We previously provided evidence that macrophages themselves secrete complement-alternative pathway components able to opsonize zymosan locally (Ezekowitz et al., J. Exp. Med. 1984. 159:244-260). We show here that covalently bound C3 cleavage products C3b and iC3b can be eluted from ...

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Publication status:
Published

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Publisher copy:
10.1172/jci112249

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The Journal of clinical investigation
Volume:
76
Issue:
6
Pages:
2368-2376
Publication date:
1985-12-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:cc74082c-8076-46ee-b323-ebc1ae4c8816
Source identifiers:
27999
Local pid:
pubs:27999

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