cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.

Journal article

RATIONALE: cAMP and cGMP are intracellular second messengers involved in heart pathophysiology. cGMP can potentially affect cAMP signals via cGMP-regulated phosphodiesterases (PDEs). OBJECTIVE: To study the effect of cGMP signals on the local cAMP response to catecholamines in specific subcellular compartments. METHODS AND RESULTS: We used real-time FRET imaging of living rat ventriculocytes expressing targeted cAMP and cGMP biosensors to detect cyclic nucleotides levels in specific locales....

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Authors: Stangherlin, A; Gesellchen, F; Zoccarato, A; Terrin, A; Fields, L

• Journal: Circulation research
• Volume: 108
• Issue: 8
• Pages: 929-939
• Publication date: 2011-04-01
• DOI: 10.1161/circresaha.110.230698
• EISSN: 1524-4571
• ISSN: 0009-7330
• Language: English
• Keywords: Animals; Cells, Cultured; Cyclic AMP; Signal Transduction; Rats; Myocytes, Cardiac; Cyclic GMP; Catecholamines; Cyclic Nucleotide Phosphodiesterases, Type 2