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cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.

Abstract:

RATIONALE: cAMP and cGMP are intracellular second messengers involved in heart pathophysiology. cGMP can potentially affect cAMP signals via cGMP-regulated phosphodiesterases (PDEs). OBJECTIVE: To study the effect of cGMP signals on the local cAMP response to catecholamines in specific subcellular compartments. METHODS AND RESULTS: We used real-time FRET imaging of living rat ventriculocytes expressing targeted cAMP and cGMP biosensors to detect cyclic nucleotides levels in specific locales....

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Journal:
Circulation research More from this journal
Volume:
108
Issue:
8
Pages:
929-939
Publication date:
2011-04-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:237737
UUID:
uuid:cc739618-711b-40a8-99fa-1412f0ba99b8
Local pid:
pubs:237737
Source identifiers:
237737
Deposit date:
2012-12-19

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