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Stereoselective spirolactam synthesis via palladium catalyzed arylative allene carbocyclization cascades.

Abstract:
A diastereoselective arylative carbocyclization of pro-nucleophile-linked allenes with aryl and heteroaryl halides to provide spirocyclic lactam products with moderate to high diastereoselectivities and good yields under Pd(0) catalysis is reported. Being operationally simple and tolerant of multiple points of diversity, this complexity building reaction cascade, in which two new carbon-carbon bonds and one new heterocyclic ring are created, should be of high value in both complex natural product synthesis as well as compound library synthesis.
Publication status:
Published

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Publisher copy:
10.1021/ol101425y

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Organic letters
Volume:
12
Issue:
17
Pages:
3784-3787
Publication date:
2010-09-01
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Source identifiers:
66120
Language:
English
Keywords:
Pubs id:
pubs:66120
UUID:
uuid:cc72b305-7f62-46ca-abdd-041ef311a222
Local pid:
pubs:66120
Deposit date:
2012-12-19

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