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Innate and adaptive immune responses in chronic HCV infection

Abstract:

Hepatitis C virus (HCV) remains a public health problem of global importance, even in the era of potent directly-acting antiviral drugs. In this chapter, I discuss immune response to acute and chronic HCV infection. The outcome of HCV infection is influenced by viral strategies that limit or delay the initiation of innate antiviral responses. This delay may enable HCV to establish widespread infection long before the host mounts effective T and B cell responses. HCV's genetic agility, resulti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Name:
National Institutes of Health
Grant:
R01AI060561, R01AI089957
Publisher:
Bentham Science Publishers
Journal:
Current Drug Targets More from this journal
Volume:
17
Publication date:
2015-01-01
DOI:
EISSN:
1873-5592
ISSN:
1389-4501
Pmid:
26302811
Language:
English
Pubs id:
pubs:542075
UUID:
uuid:cc7218c8-396a-4ebf-b680-ab3284d36b81
Local pid:
pubs:542075
Source identifiers:
542075
Deposit date:
2016-09-09

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