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A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL.

Abstract:

OBJECTIVE: Given the role of estrogen in the regulation of lipid metabolism, we screened for functional polymorphisms in the estrogen receptor alpha (ER*), and examined for their influence on serum cholesterol. METHODS AND RESULTS: We identified a novel C>T polymorphism (ERNE-145), with a minor allele frequency of 41%. This polymorphism was immediately adjacent to a putative glucocorticoid receptor (GR) binding site, which we showed to be functional by electrophoretic mobility shift analy...

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Publication status:
Published

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Journal:
Atherosclerosis More from this journal
Volume:
199
Issue:
2
Pages:
354-361
Publication date:
2008-08-01
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
Language:
English
Keywords:
Pubs id:
pubs:71877
UUID:
uuid:cc7150ec-d754-4060-8813-5c54f6c348b6
Local pid:
pubs:71877
Source identifiers:
71877
Deposit date:
2012-12-19

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