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Subtle variation in sepsis-III definitions markedly influences predictive performance within and across methods

Abstract:

Early detection of sepsis is key to ensure timely clinical intervention. Since very few end-toend pipelines are publicly available, fair comparisons between methodologies are difficult if not impossible. Progress is further limited by discrepancies in the reconstruction of sepsis onset time. This retrospective cohort study highlights the variation in performance of predictive models under three subtly different interpretations of sepsis onset from the sepsis-III definition and compares this a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-024-51989-6

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
New College
Role:
Author
ORCID:
0000-0003-0539-6414
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
ORCID:
0000-0002-9972-2809
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
14
Article number:
1920
Publication date:
2024-01-22
Acceptance date:
2024-01-11
DOI:
EISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
1598535
Local pid:
pubs:1598535
Deposit date:
2024-01-11

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