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Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies

Abstract:

Many studies in biological psychiatry compare the abundance of individual messenger RNAs between cases and control subjects or, more recently, between genotype groups. Most utilize some form of normalization procedure, usually expressing the transcript(s) of interest relative to that of a housekeeping gene or genes (also called reference genes), to overcome various sources of experimental error. Indeed, normalization is such a standard procedure that its purpose, principles, and limitations a...

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Eastwood, SL More by this author
Harrison, PJ More by this author
Journal:
Biological Psychiatry
Volume:
69
Issue:
2
Pages:
173-179
Publication date:
2011-01-15
DOI:
ISSN:
0006-3223
URN:
uuid:cc691050-2da2-46a0-b0e2-d20fb0a792b0
Source identifiers:
110391
Local pid:
pubs:110391

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