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What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

Abstract:

Background: A major handicap in developing a malaria vaccine is the difficulty in pinpointing the immune responses that protect against malaria. The protective efficacy of natural or vaccine-induced immune responses against malaria is normally assessed by relating the level of the responses in an individual at the beginning of a follow-up period and the individual's experience of malaria infection or disease during the follow-up. This approach has identified a number of important responses ag...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-8-242

Authors


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Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
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Funding agency for:
Samson M. Kinyanjui
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Funding agency for:
Faith H. Osier
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Funding agency for:
Peter C. Bull
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Funding agency for:
Kevin Marsh
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
8
Pages:
Article: 242
Publication date:
2009-10-05
DOI:
ISSN:
1475-2875
URN:
uuid:cc5e2d23-4f51-4211-ac69-d72d4be0c3ce
Local pid:
ora:3725
Language:
English
Keywords:
Subjects:

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