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What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

Abstract:

Background: A major handicap in developing a malaria vaccine is the difficulty in pinpointing the immune responses that protect against malaria. The protective efficacy of natural or vaccine-induced immune responses against malaria is normally assessed by relating the level of the responses in an individual at the beginning of a follow-up period and the individual's experience of malaria infection or disease during the follow-up. This approach has identified a number of important responses ag...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1475-2875-8-242

Authors


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Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More by this author
Institution:
"Kenyan Medical Research Institute (KEMRI), Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
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Funding agency for:
Kinyanjui, S
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Funding agency for:
Osier, F
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Funding agency for:
Bull, P
More from this funder
Funding agency for:
Marsh, K
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
8
Article number:
242
Publication date:
2009-10-01
DOI:
ISSN:
1475-2875
Language:
English
Keywords:
Subjects:
UUID:
uuid:cc5e2d23-4f51-4211-ac69-d72d4be0c3ce
Local pid:
ora:3725
Deposit date:
2010-05-06

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