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Absence of an interaction between artesunate and atovaquone--proguanil.

Abstract:

OBJECTIVE: Atovaquone plus proguanil is a new, well-tolerated and highly effective antimalarial drug. In order to protect it from the development of resistance, it may be deployed in combination with an artemisinin derivative. To investigate whether artesunate affects the pharmacokinetics of atovaquone plus proguanil, and to provide preliminary information regarding the tolerability of the triple drug combination (artesunate plus atovaquone plus proguanil), a cross over study was conducted i...

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Publication status:
Published

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Publisher copy:
10.1007/s002280050658

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Journal:
European journal of clinical pharmacology More from this journal
Volume:
55
Issue:
6
Pages:
469-474
Publication date:
1999-08-01
DOI:
EISSN:
1432-1041
ISSN:
0031-6970
Language:
English
Keywords:
Pubs id:
pubs:22079
UUID:
uuid:cc5d8d5d-c809-40c6-b2ec-7a2b0d26beea
Local pid:
pubs:22079
Source identifiers:
22079
Deposit date:
2012-12-19

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