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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.

Abstract:

We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in London, Pakistan and Singapore. We identified 20 independent SNPs associated with T2D at P < 10(-4) for testing in a replication sample of 13,170 cases and 25,398 controls, also all of South Asian ancestry. In the combined analysis, we identified common genetic variants at six ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.921

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Journal:
Nature genetics More from this journal
Volume:
43
Issue:
10
Pages:
984-989
Publication date:
2011-10-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036

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