CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis.

Journal article

CCL21 is a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cells and dendritic cells into lymphoid T areas. In human secondary lymphoid organs (SLOs), CCL21 is produced by cells distributed throughout the T zone, whereas high endothelial venules (HEVs) lack CCL21 mRNA. A critical question remains whether the development of ectopic lymphoid tissue (ELT) in chronic inflammation recapitulates the features of SLOs. Thus, we systematically investigated in situ ...

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Authors: Manzo, A; Bugatti, S; Caporali, R; Prevo, R; Jackson, D

• Publication status: Published
• Journal: American journal of pathology
• Volume: 171
• Issue: 5
• Pages: 1549-1562
• Publication date: 2007-11-01
• DOI: 10.2353/ajpath.2007.061275
• EISSN: 1525-2191
• ISSN: 0002-9440
• Language: English
• Keywords: Lichen Planus; Humans; Chronic Disease; Middle Aged; Adult; Psoriasis; Arthritis, Rheumatoid; Endothelium, Lymphatic; Male; Lymphatic Vessels; Crohn Disease; Colitis, Ulcerative; Stromal Cells; Lymph Nodes; Lymphoid Tissue; Female; Chemokine CCL21; Cell Line; Aged