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Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism.

Abstract:

Most blood plasma proteins are glycosylated. These glycoproteins typically carry sialic acid-bearing sugar chains, which can modify the observed molecular weights and isoelectric points of those proteins during electrophoretic analyses. To explore changes in protein expression and glycosylation that occurred during great ape and human evolution, we subjected multiple blood plasma samples from all these species to high-resolution proteomic analysis. We found very few species-specific differenc...

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Publication status:
Published

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Publisher copy:
10.1002/ajpa.1061

Authors


Gagneux, P More by this author
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Journal:
American journal of physical anthropology
Volume:
115
Issue:
2
Pages:
99-109
Publication date:
2001-06-05
DOI:
EISSN:
1096-8644
ISSN:
0002-9483
URN:
uuid:cc5736ef-c13b-401b-a9f9-411ad49d1277
Source identifiers:
275469
Local pid:
pubs:275469

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