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Chromophore-linked substrate (CLS405): Probing metallo-β-lactamase activity and inhibition

Abstract:

Serine- and metallo-β-lactamases present a threat to the clinical use of nearly all β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. Efforts to develop metallo-β-lactamase (MBL) inhibitors require suitable screening platforms to allow the rapid determination of β-lactamase activity and efficient inhibition. Unfortunately, the platforms currently available are not ideal for this purpose. Further progress in MBL inhibitor identification requires inexpensive and wide...

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Publisher copy:
10.1002/cmdc.201300350

Authors


Van Berkel, SS More by this author
Lejeune, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
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Journal:
ChemMedChem
Volume:
8
Issue:
12
Pages:
1923-1929
Publication date:
2013-12-05
DOI:
EISSN:
1860-7187
ISSN:
1860-7179
URN:
uuid:cc521673-9be2-4dfc-9b21-59dd08511317
Source identifiers:
444432
Local pid:
pubs:444432

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