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Spatial control of cAMP signalling in health and disease.

Abstract:

The cyclic adenosine 3',5'-monophosphate signalling pathway is now recognised to transduce signals in a compartmentalised manner such that individual stimuli only engage a subset of the pathway components that are physically constrained within defined subcellular locales, thus resulting in a precise functional outcome. As we are starting to appreciate the complexity of the spatial organisation and of the temporal regulation of this pathway, it is becoming clear that disruption of local signal...

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Publisher copy:
10.1016/j.coph.2011.09.014

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Current opinion in pharmacology More from this journal
Volume:
11
Issue:
6
Pages:
649-655
Publication date:
2011-12-01
DOI:
EISSN:
1471-4973
ISSN:
1471-4892
Language:
English
Keywords:
Pubs id:
pubs:237138
UUID:
uuid:cc4be206-ac7a-44e4-a39d-ac9dec7879d3
Local pid:
pubs:237138
Source identifiers:
237138
Deposit date:
2012-12-19

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