Spatial control of cAMP signalling in health and disease.

Journal article

Abstract:: The cyclic adenosine 3',5'-monophosphate signalling pathway is now recognised to transduce signals in a compartmentalised manner such that individual stimuli only engage a subset of the pathway components that are physically constrained within defined subcellular locales, thus resulting in a precise functional outcome. As we are starting to appreciate the complexity of the spatial organisation and of the temporal regulation of this pathway, it is becoming clear that disruption of local signal...
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Institution:

University of Oxford

Division:

MSD

Department:

Physiology Anatomy & Genetics

Role:

Author

Language:: English
Keywords:: Animals

Biological Transport

Cyclic AMP

Humans

Phosphodiesterase Inhibitors

Myocytes, Cardiac

Molecular Targeted Therapy

Second Messenger Systems

Heart Diseases
Pubs id:: pubs:237138
UUID:: uuid:cc4be206-ac7a-44e4-a39d-ac9dec7879d3
Local pid:: pubs:237138
Source identifiers:: 237138
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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