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Oxaliplatin/capecitabine vs oxaliplatin/infusional 5-FU in advanced colorectal cancer: The MRC COIN trial

Abstract:

Background: COIN compared first-line continuous chemotherapy with the same chemotherapy given intermittently or with cetuximab in advanced colorectal cancer (aCRC). Methods: Choice between oxaliplatin/capecitabine (OxCap) and oxaliplatin/leucovorin (LV)/infusional 5-FU (OxFU) was by physician and patient choice and switching regimen was allowed. We compared OxCap with OxFU and OxCapcetuximab with OxFUcetuximab retrospectively in patients and examined efficacy, toxicity profiles and the effect...

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Publisher copy:
10.1038/bjc.2012.384

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Journal:
British Journal of Cancer
Volume:
107
Issue:
7
Pages:
1037-1043
Publication date:
2012-09-25
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:cc48915f-e042-4d87-8e72-4fa45b879d40
Source identifiers:
354792
Local pid:
pubs:354792
Language:
English
Keywords:

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