FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

Journal article

Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis (P = 2.9 x 10(-4)) and Wegener's granulomatosis in two independent cohorts from the UK (P = 3 x 10(-3)) and France (P = 1.1 x 10(-4)). We did not observe this association in the organ-specific Graves'...

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Authors: Fanciulli, M; Norsworthy, P; Petretto, E; Dong, R; Harper, L

• Publication status: Published
• Journal: Nature genetics
• Volume: 39
• Issue: 6
• Pages: 721-723
• Publication date: 2007-06-01
• DOI: 10.1038/ng2046
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Disease Susceptibility; Humans; Genotype; France; Genetic Predisposition to Disease; Autoimmune Diseases; Gene Dosage; Receptors, IgG; GPI-Linked Proteins; Lupus Erythematosus, Systemic; Antigens, CD; Autoimmunity; Great Britain; Wegener Granulomatosis