Pulse pressure is independently associated with carotid plaque ulceration.

Journal article

BACKGROUND: Plaque rupture is the principal cause of acute coronary ischaemia, and unstable carotid plaques are associated with a high risk of ischaemic stroke. Carotid plaque ulceration also predicts acute coronary events, suggesting that systemic factors may determine plaque instability. One potentially important factor is pulse pressure. There is indirect evidence that cyclical haemodynamic forces affect plaque stability, and pulse pressure is a strong predictor of coronary events. OBJECT...

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Authors: Lovett, J; Howard, S; Rothwell, P

• Publication status: Published
• Journal: Journal of hypertension
• Volume: 21
• Issue: 9
• Pages: 1669-1676
• Publication date: 2003-09-01
• DOI: 10.1097/00004872-200309000-00016
• EISSN: 1473-5598
• ISSN: 0263-6352
• Language: English
• Keywords: Male; Follow-Up Studies; Aged; Carotid Stenosis; Blood Pressure; Predictive Value of Tests; Middle Aged; Cerebral Angiography; Risk Factors; Rupture; Female; Humans