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Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

Abstract:

Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). However, no genetic models exist that demonstrate their etiological relevance. To mimic the most common mutations affecting CEBPA-that is, those leading to loss of the 42 kDa C/EBPalpha isoform (p42) while retaining the 30kDa isoform (p30)-we modified the mouse Cebpa locus to express only p30. p30 supported the formation of granulocyte-macrophage progenitors. However, p42 was required for co...

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Publisher copy:
10.1016/j.ccr.2008.02.008

Authors


Kirstetter, P More by this author
Schuster, MB More by this author
Bereshchenko, O More by this author
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Journal:
Cancer cell
Volume:
13
Issue:
4
Pages:
299-310
Publication date:
2008-04-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:cc29a621-241d-4392-a796-32dcf384ec2e
Source identifiers:
324066
Local pid:
pubs:324066

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