- Abstract:
-
Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). However, no genetic models exist that demonstrate their etiological relevance. To mimic the most common mutations affecting CEBPA-that is, those leading to loss of the 42 kDa C/EBPalpha isoform (p42) while retaining the 30kDa isoform (p30)-we modified the mouse Cebpa locus to express only p30. p30 supported the formation of granulocyte-macrophage progenitors. However, p42 was required for co...
Expand abstract - Publisher copy:
- 10.1016/j.ccr.2008.02.008
-
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- Journal:
- Cancer cell
- Volume:
- 13
- Issue:
- 4
- Pages:
- 299-310
- Publication date:
- 2008-04-05
- DOI:
- EISSN:
-
1878-3686
- ISSN:
-
1535-6108
- URN:
-
uuid:cc29a621-241d-4392-a796-32dcf384ec2e
- Source identifiers:
-
324066
- Local pid:
- pubs:324066
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.
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