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Dimeric architecture of the Hendra virus attachment glycoprotein: evidence for a conserved mode of assembly

Abstract:

Hendra virus is a negative-sense single-stranded RNA virus within the Paramyxoviridae family which, together with Nipah virus, forms the Henipavirus genus. Infection with bat-borne Hendra virus leads to a disease with high mortality rates in humans. We determined the crystal structure of the unliganded six-bladed beta-propeller domain and compared it to the previously reported structure of Hendra virus attachment glycoprotein (HeV-G) in complex with its cellular receptor, ephrin-B2. As observ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/jvi.00317-10

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of virology Journal website
Volume:
84
Issue:
12
Pages:
6208-6217
Publication date:
2010-06-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:cc24aa72-4e70-4ef3-bc43-2a4be78c5ee7
Source identifiers:
52630
Local pid:
pubs:52630

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