- Abstract:
-
Vascular development and homeostasis are underpinned by two fundamental features: the generation of new vessels to meet the metabolic demands of under-perfused regions and the elimination of vessels that do not sustain flow. In this paper we develop the first multiscale model of vascular tissue growth that combines blood flow, angiogenesis, vascular remodelling and the subcellular and tissue scale dynamics of multiple cell populations. Simulations show that vessel pruning, due to low wall she...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00285-008-0213-z
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- Journal:
- Journal of mathematical biology
- Volume:
- 58
- Issue:
- 4-5
- Pages:
- 689-721
- Publication date:
- 2009-04-05
- DOI:
- EISSN:
-
1432-1416
- ISSN:
-
0303-6812
- URN:
-
uuid:cc21dee2-d836-472c-823d-d908cdcf9855
- Source identifiers:
-
12139
- Local pid:
- pubs:12139
- Copyright date:
- 2009
Journal article
Angiogenesis and vascular remodelling in normal and cancerous tissues.
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