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Angiogenesis and vascular remodelling in normal and cancerous tissues.

Abstract:

Vascular development and homeostasis are underpinned by two fundamental features: the generation of new vessels to meet the metabolic demands of under-perfused regions and the elimination of vessels that do not sustain flow. In this paper we develop the first multiscale model of vascular tissue growth that combines blood flow, angiogenesis, vascular remodelling and the subcellular and tissue scale dynamics of multiple cell populations. Simulations show that vessel pruning, due to low wall she...

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Publication status:
Published

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Publisher copy:
10.1007/s00285-008-0213-z

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of mathematical biology
Volume:
58
Issue:
4-5
Pages:
689-721
Publication date:
2009-04-05
DOI:
EISSN:
1432-1416
ISSN:
0303-6812
URN:
uuid:cc21dee2-d836-472c-823d-d908cdcf9855
Source identifiers:
12139
Local pid:
pubs:12139

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