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The p53 response: a new mitochondrial role for cofactor strap

Abstract:

Strap is a DNA damage responsive p53 cofactor, reflecting its control by the DNA damage signalling pathway. This study identified Strap at the mitochondria where it is damage regulated and can augment p53-dependent cytochrome c release leading to apoptosis. Moreover, p53 and Strap facilitate each other’s localisation from the mitochondria to the nucleus during the DNA damage response. Two ATM/ATR phosphorylation consensus sites in Strap were identified by mass spectrometry and phosphorylat...

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Institution:
University of Oxford
Oxford college:
Linacre College
Department:
Medical Sciences Division - Clinical Pharmacology
Role:
Author

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:cc1f9ba3-5a69-4e95-8a28-b7dbe1e7109c
Local pid:
ora:8521
Language:
English
Keywords:
Subjects:

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