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Variants of the EAAT2 glutamate transporter gene promoter are associated with cerebral palsy in preterm infants

Abstract:

Preterm delivery is associated with neurodevelopmental impairment caused by environmental and genetic factors. Dysfunction of the excitatory amino acid transporter 2 (EAAT2) and the resultant impaired glutamate uptake can lead to neurological disorders. In this study, we investigated the role of single nucleotide polymorphisms (SNPs; g.-200C>A and g.-181A>C) in the EAAT2 promoter in susceptibility to brain injury and neurodisability in very preterm infants born at or before 32-week gest...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s12035-017-0462-1

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Name:
University of the West of England
Publisher:
Springer US
Journal:
Molecular Neurobiology More from this journal
Volume:
55
Issue:
3
Pages:
2013–2024
Publication date:
2017-03-09
Acceptance date:
2017-02-16
DOI:
EISSN:
1559-1182
ISSN:
0893-7648
Keywords:
Pubs id:
pubs:684991
UUID:
uuid:cc1ae17a-ca0e-4ec4-8fbf-2f6d38f50ff7
Local pid:
pubs:684991
Source identifiers:
684991
Deposit date:
2017-04-27

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