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Journal article

High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacy

Abstract:

Few studies have examined the efficacy of antiretroviral therapy (ART) in the context of cell-to-cell transmission. We aimed to determine whether the activity of ART is limited by the mode of HIV-1 spread between cells and the type of immune cell implicated in transmission, or is independent of these variables.ART activity was evaluated in primary cells using in-vitro cell-free and cell to-cell HIV-1 infection systems.HIV-1 cell-free or cell-to-cell transmission between infected monocyte-deri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/qad.0b013e3283632ec4

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Lippincott, Williams & Wilkins
Journal:
AIDS More from this journal
Volume:
27
Issue:
14
Pages:
2201–2206
Publication date:
2013-09-10
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Language:
English
Keywords:
Pubs id:
pubs:421086
UUID:
uuid:cc16025f-5d46-4f13-b15f-b98b8354d932
Local pid:
pubs:421086
Source identifiers:
421086
Deposit date:
2013-11-16

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