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Journal article

10 years of GWAS discovery: biology, function, and translation

Abstract:
Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ajhg.2017.06.005

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
Green Templeton College
Role:
Author
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gs2:Sylvia and Charles Viertel Charitable Foundation More from this funder
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Publisher:
Cell Press Publisher's website
Journal:
American Journal of Human Genetics
Volume:
101
Issue:
1
Pages:
5-22
Publication date:
2017-07-06
Acceptance date:
2017-06-07
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Source identifiers:
706565
Language:
English
Keywords:
Pubs id:
pubs:706565
UUID:
uuid:cc102ef6-eb94-4bdf-be10-36a85d5d7e16
Local pid:
pubs:706565
Deposit date:
2017-07-19

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