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Anionic phospholipid interactions with the potassium channel KcsA: simulation studies.

Abstract:

Molecular dynamics (MD) simulations have been used to unmask details of specific interactions of anionic phospholipids with intersubunit binding sites on the surface of the bacterial potassium channel KcsA. Crystallographic data on a diacyl glycerol fragment at this site were used to model phosphatidylethanolamine (PE), or phosphatidylglycerol (PG), or phosphatidic acid (PA) at the intersubunit binding sites. Each of these models of a KcsA-lipid complex was embedded in phosphatidyl choline bi...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.105.071407
Journal:
Biophysical journal More from this journal
Volume:
90
Issue:
3
Pages:
822-830
Publication date:
2006-02-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495

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