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Effects of acetylcholinesterase and butyrylcholinesterase on cell survival, neurite outgrowth, and voltage-dependent calcium currents of embryonic ventral mesencephalic neurons.

Abstract:

The aim of this study was to investigate the effect of butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) on cell survival, neurite outgrowth and voltage-dependent calcium currents in developing rat ventral mesencephalic (VM) neurons. Both BuChE and AChE have been shown to promote neurite outgrowth in postnatnal preparations. However, the effect of these substances has never been investigated on rat embryonic VM cells, which are used in animal models of foetal transplantation as a ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Experimental neurology
Volume:
184
Issue:
1
Pages:
496-509
Publication date:
2003-11-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:cc0cdd25-313f-47d0-a6bf-28085d234c24
Source identifiers:
185154
Local pid:
pubs:185154

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