Journal article
A comprehensive model for the proliferation–quiescence decision in response to endogenous DNA damage in human cells
- Abstract:
-
Human cells that suffer mild DNA damage can enter a reversible state of growth arrest known as quiescence. This decision to temporarily exit the cell cycle is essential to prevent the propagation of mutations, and most cancer cells harbor defects in the underlying control system. Here we present a mechanistic mathematical model to study the proliferation-quiescence decision in nontransformed human cells. We show that two bistable switches, the restriction point (RP) and the G1/S transition, m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 115
- Issue:
- 10
- Pages:
- 2532-2537
- Publication date:
- 2018-02-20
- Acceptance date:
- 2017-01-29
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Pmid:
-
29463760
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:826296
- UUID:
-
uuid:cc0b67e1-5bc5-4f7e-b1f7-8f7668f2ddaa
- Local pid:
- pubs:826296
- Source identifiers:
-
826296
- Deposit date:
- 2018-02-23
Terms of use
- Copyright holder:
- Heldt et al
- Copyright date:
- 2018
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from the National Academy of Sciences at: https://doi.org/10.1073/pnas.1715345115
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