Journal article icon

Journal article

A comprehensive model for the proliferation–quiescence decision in response to endogenous DNA damage in human cells

Abstract:

Human cells that suffer mild DNA damage can enter a reversible state of growth arrest known as quiescence. This decision to temporarily exit the cell cycle is essential to prevent the propagation of mutations, and most cancer cells harbor defects in the underlying control system. Here we present a mechanistic mathematical model to study the proliferation-quiescence decision in nontransformed human cells. We show that two bistable switches, the restriction point (RP) and the G1/S transition, m...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1073/pnas.1715345115

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Queens College
Role:
Author
ORCID:
0000-0002-9276-5013
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/M00354X/1
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
115
Issue:
10
Pages:
2532-2537
Publication date:
2018-02-20
Acceptance date:
2017-01-29
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
29463760
Language:
English
Keywords:
Pubs id:
pubs:826296
UUID:
uuid:cc0b67e1-5bc5-4f7e-b1f7-8f7668f2ddaa
Local pid:
pubs:826296
Source identifiers:
826296
Deposit date:
2018-02-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP