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The role of cyclin E1 expression on sensitivity to DNA damage response modulators in Osteosarcoma

Abstract:

Osteosarcoma (OS) is an aggressive malignant bone tumour mostly present in childhood. In particular, the retinoblastoma tumour suppressor gene (RB1) has an essential role in the pathogenesis of OS. In response to growth stimuli, an altered Retinoblastoma/E2F pathway mediates an aberrant expression of downstream cell cycle promoters. Specifically, ectopic expression of cyclin E1 accelerates DNA replication timing leading to genomic instability and DNA replication stress. Consequently, DNA r...

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Division:
MSD
Department:
Oncology
Role:
Author

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:cc0a8aac-25ef-4ed8-b3cb-f5e233bb5ec7
Deposit date:
2020-04-30

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