Journal article icon

Journal article

EZH2 promotes proliferation and invasiveness of prostate cancer cells.

Abstract:

BACKGROUND: The transcriptional repressor EZH2 is implicated in control of cell proliferation in embryonic, immortalized and transformed cells. EZH2 expression in prostate cancer correlates with progression to hormone-refractory and metastatic disease, but it is unknown whether EZH2 plays a specific role in the acquisition of an advanced prostate cancer phenotype. METHODS: Using siRNA knockdown, we investigated the role of EZH2 in maintenance of prostate cancer cell proliferation and invasive...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/pros.20550

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
Cunliffe, VT More by this author
Journal:
The Prostate
Volume:
67
Issue:
5
Pages:
547-556
Publication date:
2007-04-05
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
URN:
uuid:cc07e40f-c14c-4a95-9a62-ebad407ff884
Source identifiers:
120622
Local pid:
pubs:120622

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP