- Abstract:
-
BACKGROUND: The transcriptional repressor EZH2 is implicated in control of cell proliferation in embryonic, immortalized and transformed cells. EZH2 expression in prostate cancer correlates with progression to hormone-refractory and metastatic disease, but it is unknown whether EZH2 plays a specific role in the acquisition of an advanced prostate cancer phenotype. METHODS: Using siRNA knockdown, we investigated the role of EZH2 in maintenance of prostate cancer cell proliferation and invasive...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/pros.20550
-
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- Journal:
- The Prostate
- Volume:
- 67
- Issue:
- 5
- Pages:
- 547-556
- Publication date:
- 2007-04-05
- DOI:
- EISSN:
-
1097-0045
- ISSN:
-
0270-4137
- URN:
-
uuid:cc07e40f-c14c-4a95-9a62-ebad407ff884
- Source identifiers:
-
120622
- Local pid:
- pubs:120622
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
EZH2 promotes proliferation and invasiveness of prostate cancer cells.
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