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Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis

Abstract:
Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The utility of these improved pulse sequences is demonstrated in a metabolomic study of multiple sclerosis (MS) patients.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c9an01005j

Authors


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Role:
Author
ORCID:
0000-0001-9181-8892
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0001-5583-6460
Publisher:
Royal Society of Chemistry
Journal:
Analyst More from this journal
Volume:
144
Issue:
24
Pages:
7270-7277
Publication date:
2019-11-06
Acceptance date:
2019-10-15
DOI:
EISSN:
1364-5528
ISSN:
0003-2654
Pmid:
31693024
Language:
English
Keywords:
Pubs id:
pubs:1070618
UUID:
uuid:cc0504e2-d188-4d61-a812-f60efffb1fef
Local pid:
pubs:1070618
Source identifiers:
1070618
Deposit date:
2019-11-29

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