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The synthesis of (+)-pericosine B

Abstract:

The first synthesis of (+)-pericosine B is described; this takes seven steps and proceeds in 10% overall yield. The key step in our work is a hydrogen-bonding controlled contra-steric dihydroxylation reaction using osmium tetroxide and an amine promoter. The absolute stereochemistry of the natural product was deduced from the known absolute stereochemistry of our starting material and moreover, the relative and absolute stereochemistry of our synthetic material was determined unambiguously fr...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Helliwell, M More by this author
Waring, MJ More by this author
Newcombe, NJ More by this author
Journal:
TETRAHEDRON LETTERS
Volume:
39
Issue:
48
Pages:
8755-8758
Publication date:
1998-11-26
DOI:
ISSN:
0040-4039
URN:
uuid:cc026e8a-97ca-43b7-9a7d-965e536e09d8
Source identifiers:
36791
Local pid:
pubs:36791
Language:
English

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